Zoology Faculty Work
Title
Genetic Determinants of Voluntary Exercise
Document Type
Article
Publication Date
2013
Publication Title
Trends in Genetics
Volume Number
29
Issue Number
6
DOI
10.1016/j.tig.2012.12.007
Abstract
Variation in voluntary exercise behavior is an important determinant of long-term human health. Increased physical activity is used as a preventative measure or therapeutic intervention for disease, and a sedentary lifestyle has generally been viewed as unhealthy. Predisposition to engage in voluntary activity is heritable and induces protective metabolic changes, but its complex genetic/genomic architecture has only recently begun to emerge. We first present a brief historical perspective and summary of the known benefits of voluntary exercise. Second, we describe human and mouse model studies using genomic and transcriptomic approaches to reveal the genetic architecture of exercise. Third, we discuss the merging of genomic information and physiological observations, revealing systems and networks that lead to a more complete mechanistic understanding of how exercise protects against disease pathogenesis. Finally, we explore potential regulation of physical activity through epigenetic mechanisms, including those that persist across multiple generations.
ISSN
0168-9525
First Page
348
Last Page
357
Recommended Citation
Kelly, Scott and Pomp, Daniel, "Genetic Determinants of Voluntary Exercise" (2013). Zoology Faculty Work. 67.
https://digitalcommons.owu.edu/zool_pubs/67
Link Out URL
https://doi.org/10.1016/j.tig.2012.12.007