Chemistry Faculty Work
Title
Heterocyclic Methylsulfone Hydroxamic Acid LpxC Inhibitors as Gram-Negative Antibacterial Agents
Document Type
Article
Publication Date
2012
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume Number
22
Issue Number
22
DOI
10.1016/j.bmcl.2012.09.058
Abstract
The synthesis and antibacterial activity of heterocyclic methylsulfone hydroxamates is presented. Compounds in this series are potent inhibitors of the LpxC enzyme, a key enzyme involved in the production of lipopolysaccharide (LPS) found in the outer membrane of Gram-negative bacteria. SAR evaluation of compounds in this series revealed analogs with potent antibacterial activity against challenging Gram-negative species such as Pseudomonas aeruginosa and Klebsiella pneumoniae.
ISSN
0960-894X
First Page
6832
Last Page
6838
Recommended Citation
Mitton-Fry, Mark; McAllister, Laura; and Menard, Carol, "Heterocyclic Methylsulfone Hydroxamic Acid LpxC Inhibitors as Gram-Negative Antibacterial Agents" (2012). Chemistry Faculty Work. 13.
https://digitalcommons.owu.edu/chem_pubs/13
Link Out URL
https://doi.org/10.1016/j.bmcl.2012.09.058