Chemistry Faculty Work
Title
Novel Quinoline Derivatives as Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV
Document Type
Article
Publication Date
2013
Publication Title
Bioorganic & Medicinal Chemistry Letters
Volume Number
23
Issue Number
10
DOI
10.1016/j.bmcl.2013.03.047
Abstract
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
ISSN
0960-894X
First Page
2955
Last Page
2961
Recommended Citation
Mitton-Fry, Mark; Brickner, Steven; and Hamel, Judith, "Novel Quinoline Derivatives as Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV" (2013). Chemistry Faculty Work. 10.
https://digitalcommons.owu.edu/chem_pubs/10
Link Out URL
https://doi.org/10.1016/j.bmcl.2013.03.047
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