Title
Progress Toward the Total Synthesis of Cryptocaryol A
Document Type
Article
Publication Date
4-20-2016
Abstract
Cryptocaryol A is a stereochemically complex natural product with potential anticancer properties. A convergent, stereoselective, and concise (11-step) total synthesis has been devised, and progress toward the completion of this synthesis is reported. The stereocenters have been installed using a combination of asymmetric allylation using Leighton's reagent and internal stereorelay. Key steps include an asymmetric bis-allylation, terminus differentiation via ring-closing metathesis, a chemoselective alkene oxidation using ozone, and a boron aldol reaction with 1,5-anti stereoinduction.
Faculty Mentor
Mark Mitton-Fry
Recommended Citation
Boedicker, Erin and Li, Zhiyao, "Progress Toward the Total Synthesis of Cryptocaryol A" (2016). Student Symposium. 42.
http://digitalcommons.owu.edu/student-symposium/42
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