Chemistry Faculty Work
Title
Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity
Document Type
Article
Publication Date
2013
Publication Title
Journal of Medicinal Chemistry
Volume Number
56
Issue Number
13
DOI
10.1021/jm400560z
Abstract
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1.
ISSN
0022-2623
First Page
5541
Last Page
5552
Recommended Citation
Mitton-Fry, Mark; Brown, Matthew; and Arcari, Joel, "Pyridone-Conjugated Monobactam Antibiotics with Gram-Negative Activity" (2013). Chemistry Faculty Work. 7.
https://digitalcommons.owu.edu/chem_pubs/7
Link Out URL
https://doi.org/10.1021/jm400560z