Title

Novel Quinoline Derivatives as Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV

Document Type

Article

Publication Date

2013

Publication Title

Bioorganic & Medicinal Chemistry Letters

Volume Number

23

Issue Number

10

DOI

10.1016/j.bmcl.2013.03.047

Abstract

A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.

ISSN

0960-894X

First Page

2955

Last Page

2961

Link Out URL

https://doi.org/10.1016/j.bmcl.2013.03.047

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