Novel Quinoline Derivatives as Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV
Bioorganic & Medicinal Chemistry Letters
A structurally novel set of inhibitors of bacterial type II topoisomerases with potent in vitro and in vivo antibacterial activity was developed. Dual-targeting ability, hERG inhibition, and pharmacokinetic properties were also assessed.
Mitton-Fry, Mark; Brickner, Steven; and Hamel, Judith, "Novel Quinoline Derivatives as Inhibitors of Bacterial DNA Gyrase and Topoisomerase IV" (2013). Chemistry Faculty Work. 10.
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